The Difference Between Gout and Pseudogout

Pseudogout is a not so well known disease which shows the similar symptoms or effects as gout. Just like gout, it is also a form of arthritis that attacks suddenly and gives a painful swelling inflammation in one or more of your joints.

Gout is the result of too much urid acid in the body that causes crystallization that forms a type of fine crystals which is scientifically known as monosodium urate. On the other hand pseudogout is caused by the deposition of calcium pyrophosphate crystals in the synovial fluid of joints. Pseudogout is often referred to as Calcium Pyprophosphate Deposition Disease, CPPD.

Thus, what differentiates between gout and CPPD is the type of crystal deposits. Since number of gout cases is many times greater than the cases of CPPD which makes gout a more popular and this is why CPPD is known as pseudogout which literally means "false gout".

Pseudogout usually occurs in individuals of age 50 and above. One interesting fact is, pseudogout tend to attack women more frequently while in the case of gout, it is men that dominate more 90 percent of the cases.

Reports show that pseudogout can occasionally coexist with gout. This means that both of those types of crystal can be found in the same joint fluid at times. Researchers have also noted that the cartilage is more calcified when both forms of deposits is found in a particular joint.

While gout can be diagnosed by observing the symptoms of the affected joints and confirmed with the uric acid level in the blood test report (although there some cases where gout attacks people with healthy uric acid level).

Since there is not direct correlation between pseudogout with any of the elements in the blood test, the most accurate water to diagnose whether a patient is having CPPD is through X-ray. This is because pseudogout is a type of calcifications known as chondocalcinosis and calcium compound deposit is visible on the X-ray films.

Another way to differentiate gout from pseudogout in the lab is through examination of the synovial fluid from the joint. Under a special powerful microscope called polarizing microscope, the calcium pyrophosphate crystals can be identified because both types of crystals have very different chemical structure.

Treatments for pseudogout are same as the treatments for gout. This is because both cases have the same immune reactions that cause inflammation and pain regardless of what type of crystal that triggers it. Thus, colchicines and NSAIDs (ibuprofen) are applicable to pseudogout patients. The only exception is allopurinol which controls the uric acid level in the blood, it will be useless in the case of CPPD.

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